This book illustrates how the retrosynthetic tool, widely used by academics in the search for synthetic routes used to prepare novel organic compounds, is applied in the Pharmaceutical Industry. However, merely finding a viable synthetic route is not sufficient. Many different options have to be considered and evaluated, as there exist numerous constraints on the industrialist in terms of what can and what cannot be reduced to practice. The reader will be guided through the various steps leading to the best processes and the limits encountered if these are put into practise on an industrial scale of seven key Active Pharmaceutical Ingredient (API). Thereafter, an evaluation the potential each process has for implementation is presented. It merges the two points of view, of retrosynthesis, and process chemistry, showing how retrosynthetic analysis is helpful in selecting the most efficient route for an industrial synthesis of a particular compound whilst giving insight into the industrial process per se. Some key concepts used by process chemists to improve efficiency (e.g. convergent/linear routes, placement of a low yield step) are used to indicate the best route to select, as most of these factors are not usually considered by academic organic chemists. One chapter is dedicated to each drug, with each containing the following information: 1)牋牋 Worldwide sales and patent status of the Active Pharmaceutical Ingredient (API) 2)牋牋 Structure analysis and general retrosynthetic strategy of the API (main features and challenges for the chemist) 3)牋牋 First reported synthesis 4)牋牋 Critical analysis of the processes which have been developed and. comparison of the synthetic routes. 5)牋牋 Lessons learned (key ideas to be retained that can be applied for other molecules and situations) 6)牋牋 Reaction conditions for Schemes A to X 7)牋牋 Chemical highlights on key reactions used during the synthesis 8)牋牋 References A unique feature of this book is the use of reaction maps (likened to underground/metro maps) which display several synthetic processes in the same scheme. The reaction maps allow easy comparison of the different routes which give the same molecule or intermediate.

• 关于产品：
• ● 正版保障：本网站隶属于中国国际图书贸易集团公司，确保所有图书都是100%正版。
• ● 环保纸张：进口图书大多使用的都是环保轻型张，颜色偏黄，重量比较轻。
• ● 毛边版：即书翻页的地方，故意做成了参差不齐的样子，一般为精装版，更具收藏价值。
• 
  关于退换货：
• 由于预订产品的特殊性，采购订单正式发订后，买方不得无故取消全部或部分产品的订购。
• 由于进口图书的特殊性，发生以下情况的，请直接拒收货物，由快递返回：
• ● 外包装破损/发错货/少发货/图书外观破损/图书配件不全（例如：光盘等）
  并请在工作日通过电话400-008-1110联系我们。
• 签收后，如发生以下情况，请在签收后的5个工作日内联系客服办理退换货：
• ● 缺页/错页/错印/脱线
• 
  关于发货时间：
• 一般情况下：
• ●【现货】 下单后48小时内由北京（库房）发出快递。
• ●【预订】【预售】下单后国外发货，到货时间预计5-8周左右，店铺默认中通快递，如需顺丰快递邮费到付。
• ● 需要开具发票的客户，发货时间可能在上述基础上再延后1-2个工作日（紧急发票需求，请联系010-68433105/3213）；
• ● 如遇其他特殊原因，对发货时间有影响的，我们会第一时间在网站公告，敬请留意。
• 
  关于到货时间：
• 由于进口图书入境入库后，都是委托第三方快递发货，所以我们只能保证在规定时间内发出，但无法为您保证确切的到货时间。
• ● 主要城市一般2-4天
• ● 偏远地区一般4-7天
• 
  关于接听咨询电话的时间：
• 010-68433105/3213正常接听咨询电话的时间为：周一至周五上午8：30～下午5：00，周六、日及法定节假日休息，将无法接听来电，敬请谅解。
• 其它时间您也可以通过邮件联系我们：customer@readgo.cn,工作日会优先处理。
• 
  关于快递：
• ● 已付款订单：主要由中通、宅急送负责派送，订单进度查询请拨打010-68433105/3213。