Arsenic:Exposure Sources, Health Risks, and Mechanisms of Toxicity

砷:暴露源、健康风险与毒性机制

环境工程学

售   价:
1756.00
发货周期:预计3-5周发货
作      者
出  版 社
出版时间
2015年10月23日
装      帧
精装
ISBN
9781118511145
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页      码
576
开      本
155.6x235mm
语      种
英文
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库存 30 本
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图书简介
This book acts as a compendium of up-to-date knowledge on arsenic as a toxicant, its exposure sources, health risks, and mechanisms. The chapters are divided into key sections that cover Fundamentals of Arsenic Exposure and Metabolism, Epidemiology and Disease Manifestations of Arsenic Exposure, and Mechanisms of Toxicity. The book begins by introducing the fundamentals and history of arsenic, common sources of exposure, and chemical and biochemical properties. It provides an understanding about the potential health risks and discusses ways that toxicological research can improve and contribute to characterization and risk assessment of arsenic exposure.This book covers a variety of specific topics, like the role of genetics and susceptibility in arsenic-induced cancer, dose and time dependence of response, and detoxification. It discusses several arsenic-induced diseases like chronic arseniasis, lung cancer, pulmonary diseases, bladder cancer, cardiovascular disease, neurological diseases, diabetes, and hepatoxicity. The book includes evidence from human population studies, animal models, toxicokinetic and pharmacokinetic models, and mechanistic insights, such as arsenics roles in chemotherapy, genotoxicity, stem cell simulation, and epigenetics.
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