Chemokines and Viral Infection(Current Topics in Microbiology and Immunology)

医学生物化学

原   价:
1658.00
售   价:
1326.00
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平台大促 低至8折优惠
发货周期:预计8-10周发货
作      者
出  版 社
出版时间
2006年03月02日
装      帧
精装
ISBN
9783540292074
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页      码
160
开      本
语      种
英文
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图书简介
Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. Within a relatively short period of time, early participants within the field determined that these proteins displayed distinct and conserved structural features and exerted potent chemotactic effects on defined lymphocyte subsets. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection.
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