图书简介
Aimed at advanced undergraduates, postgraduates and researchers, this important textbook provides a detailed description of the structure and mechanisms of phosphoinositide 3-kinase (PI3Ks) signalling of all classes, with focus on the cellular context of PI3K activity, including its relevance to normal tissue and diseased states. This book contains a general review chapter detailing the mechanisms of cell proliferation and apoptosis, which are two of the main cellular targets of PI3K signalling. In addition, it provides a detailed
Introduction (E W-F Lam); Cell Proliferation and Cell Death; In Vivo Roles of Cell Cycle and Apoptosis Regulators; The Role of Phosphoinositide 3-Kinase in Proliferation and Apoptosis (A Sunters & E W-F Lam); Phosphoinositide 3-Kinase Signalling Pathway; Class IA PI3K Enzymes; Class IB PI3K Enzymes; Class II PI3K Enzymes; Class III PI3K Enzymes; Expression of PI3K Enzymes; 3-Phosphoinositide Binding Domains; Downstream Targets of 3-Phosphoinositide; Manipulation of PI3K Enzyme Expression; Biological Role of PI3K Signalling Pathway; Phosphoinositide Phosphatases; The Role of the PI3K Pathway in Disease (J Domin); PI3K Signalling to Cell Survival and Proliferation; Molecules Directly Regulated by D3 Lipids; Genetic Studies of PI3K Function in Model Organisms; Molecules Downstream of PI3K and D3 Lipids; PI3K Regulation of Cell Survival; Signalling from PI3K to Cell Proliferation; Alterations of PI3K and Its Pathways in Cancer; Cancer Therapeutics (P Brennan); FOXO Transcription Factors; Forkhead Transcription Factors; FOXO Transcription Factors; Signalling to FOXO Proteins; Cellular Relocation Mechanism; FOXO Protein Processing; Transcriptional Activity of FoxO Proteins; Functions of FOXO in Vivo; FOXO Targets and Function; FOXO Proteins in Transformation and Diseases (S Fernandez de Mattos et al.).
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